Scientist Seth Brundle is remembered today as one of the fathers of early teleportation technology. As far back as 1986, Brundle successfully teleported inorganic matter from one telepod to another. What's more, Brundle's method avoided the disastrous Jaunt effect. Following a failed (and messy) first attempt, he safely teleported a live, conscious baboon across a Toronto apartment.
Given enough time, who knows what Brundle might have accomplished? But rushed by a pending magazine publication, the overzealous scientist teleported himself -- and it would have worked swimmingly if a common housefly hadn't snuck in there with him. See, while the teleportation computer had factored in the some 100 trillion microbes thriving in Brundle's body, the program didn't know what to make of the housefly.
Brundle emerged from the second telepod seemingly unchanged, but the computer had fused the fly DNA with his own. As a result, Brundle suffered a catastrophic metamorphosis into a hybrid "Brundlefly" creature.
Ever the scientist, Brundle developed a hypothetical cure, by which he would splice himself with a second human test subject, producing an entirely new human being -- as well as a monstrous byproduct made of all that garbage DNA. Fortunately, Brundle died before he could test the method out on his lover and unborn child.
Three years later, Brundle's son Martin (also afflicted by spliced human/fly DNA) succeeded in carrying out his father's horrifying cure, though at the expense of industrialist Anton Bartok's life.
In the end, some DNA was spliced, some baboons were everted and a handful of hideous monstrosities were unleashed on humanity, but the age of teleportation was born.