It's a Mad World
If you think determining how genetics affects mental health is fraught, trying to figure out how nongenetic factors could lead to mental disorders can throw you for an even bigger loop.
How far back in a person's life do we look for an environmental trigger? How do we safeguard against ignoring a less catastrophic event (an allergy), and singling out only events we find compelling (the use of psychotropic drugs)? How can we determine if a genetic component interacts with an environmental one?
The latter scenario is probably the trickiest but also extremely likely. Most mental health experts believe that a combination of genetic factors and exposure to environmental factors cause mental illness. It's multifactorial. And schizophrenia is back to bolster that claim.
A study by the Swiss Federal Institute of Technology found some rather startling news about how environmental factors might contribute to a schizophrenic mind -- and when those factors might be most poised to come into play. Using mice that were specially bred to complete a life cycle at a faster rate, they found that a viral infection or influenza during the first stages of a mother's pregnancy, combined with exposure to major stress during puberty, increased the likelihood of the mice developing schizophrenic-like brain functioning [source: Rüegg]. Now don't get too alarmed; researchers pointed out that it's not uncommon for mothers to get infections in pregnancy. Nor should you throw in the towel if you had a stressful middle school experience. Since only 1 percent of the population is schizophrenic, the flu and bullying does not a schizophrenic make.
We also know that brain chemistry must play a part in mental illness, because we know that giving people medication that addresses brain chemistry often works to regulate or resolve the disorder. But observing brain biochemistry isn't an easy process; you can't exactly crack open a person's head and ask them to say "ahh." What we do know is that our brain cells (or neurons) are excited or inhibited by neurotransmitters. And if we have abnormal amounts (large or small) of these neurotransmitters, we might observe a marked deviation in behavior or mood.
So there you have it: We don't know the exact causes of mental illness, but we have some really compelling cases for several factors.
Author's Note: What causes mental illness?
If you're really interested in what causes mental illness, three pages won't do. Research these days is being done at a steady clip to find any indications how genetics or outside influences affect the functioning of the human brain. To keep up to date, don't feel the need to subscribe to the heady scientific journals; just keep up with the news.
- Chudler, Eric H. "Schizophrenia." Neuroscience for Kids; University of Washington. March 1, 2013. (March 5, 2013) http://faculty.washington.edu/chudler/schiz.html
- Encyclopædia Britannica. "Mental Disorder." Encyclopædia Britannica Online Library Edition. 2013. (March 5, 2013) http://www.library.eb.com/eb/article-32320
- Healy, Melissa. "Spanking linked to increased risk of mental problems." Los Angeles Times. July 2, 2012. (March 5, 2013) http://articles.latimes.com/2012/jul/02/news/la-heb-spanking-mental-health-problems-20120702
- Hyman, Steven E. "The genetics of mental illness: implications for practice." Bulletin of the World Health Organizations. 2000. (March 5, 2013) http://www.who.int/bulletin/archives/78(4)455.pdf
- Kolata, Gina. "5 Disorders Share Genetic Risk Factors, Study Finds." The New York Times. Feb. 28, 2013. (March 5, 2013) http://www.nytimes.com/2013/03/01/health/study-finds-genetic-risk-factors-shared-by-5-psychiatric-disorders.html?ref=ginakolata&_r=0
- Mayo Clinic. "Mental Illness." Mayo Clinic. 2013. (March 5, 2013) http://www.mayoclinic.com/health/mental-illness/DS01104/DSECTION=causes
- Rüegg, Peter. "Malign environmental combination favours schizophrenia." Swiss Federal Institute of Technology Zurich. Feb. 28, 2013. (March 5, 2013) http://www.ethlife.ethz.ch/archive_articles/130301_schizophrenie_per/index_EN
- Rutter, Michael. "How the environment affects mental health." The British Journal of Psychiatry. Nov. 8, 2004. (March 5, 2013) http://bjp.rcpsych.org/content/186/1/4.full
- Schmidt, Charles W. "Environmental Connections: A deeper look into mental illness." Environmental Health Perspectives. August 2007. (March 5, 2013) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1940091/
- Weir, Kirsten. "The roots of mental illness." Monitor on Psychology. June 2012. (March 5, 2013) http://www.apa.org/monitor/2012/06/roots.aspx