If Santorio Santorio established a proud tradition of self-sacrifice in the field of metabolic research, then perhaps his greatest heir was Dr. Elsie Widdowson. For much of her 60 years of study of nutrition and metabolism, the 20th-century British researcher used herself as a willing test subject in her experiments.
In her early career, Widdowson and her long-time collaborator Dr. R.A. McCance combined their research on fruits, vegetables and meats to write "The Chemical Composition of Foods," a landmark book on nutrition still in use today. It was World War II, however, that led Widdowson and her colleague to self-experiment. Because the British government was rationing food, Widdowson decided to determine what healthy diet could be had from the meager and somewhat random assortments of foods that were most widely available to the average Briton during the war. Putting herself on starvation diets, Widdowson produced a diet founded on cabbage, potatoes and bread that could keep a person in good health and submitted it to the British government, which championed it [source: Martin]. To prove their diet, Widdowson and McCance showed it could sustain even the most brutal calorie-burning regimen. While half-starved, the two took to the mountains for grueling workouts, in one day burning 4,700 calories by walking 36 miles (58 kilometers) and climbing 7,000 feet (2.13 kilometers). Keep in mind that the average daily energy expenditure for a female is around 2,200 calories [source: Martin, Smith]. Their diet findings were used to help feed starved Holocaust survivors.
Widdowson also self-experimented with other aspects of diet, including determining salt intake and through self-injecting iron, she found that the mineral is regulated in the body through absorption, not excretion, a finding that forms the basis for treating anemia [source: MRC].
- Abbot, Dr. Bruce. "Human memory: Herman Ebbinghaus." Indiana University - Perdue University Ft. Wayne. Accessed September 1, 2011. http://users.ipfw.edu/abbott/120/Ebbinghaus.html
- Altman, Lawrence K. "Who Goes First? The story of self-experimentation in medicine." University of California Press. 1998. http://www.ucpress.edu/book.php?isbn=9780520212817
- Cohen, A. "Should we tolerate tolerability as an objective in early drug development?" British Journal of Clinical Pharmacology. September 2007. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000647/
- Cullari, Salvatore. "Re: upside down glasses?" MadSci Network. March 21, 1997. http://www.madsci.org/posts/archives/1997-03/858984531.Ns.r.html
- Martin, Douglas. "Elsie Widdowson,93, a pioneer in nutrition." New York Times. June 26, 2000. http://www.nytimes.com/2000/06/26/world/elsie-widdowson-93-a-pioneer-in-nutrition.html?pagewanted=all&src=pm
- Minkel, JR. "Self-experimenters step up for science." Scientific American. March 10, 2008. http://www.scientificamerican.com/article.cfm?id=self-experimenters
- MRC Human Nutrition Research. "Dr. Elsie Widdowson, CH CBE, FRS." Accessed September 6, 2011. http://www.mrc-hnr.cam.ac.uk/about/elsie-widdowson.html
- Neuringer, Allen. "Self-experimentation: A call for change." Behaviorism. Spring 1981. http://academic.reed.edu/psychology/docs/SelfExperimentation.pdf
- NNDB. "Albert Hoffman." Accessed September 2, 2011. http://www.nndb.com/people/613/000022547/
- NobelPrize.org. "Blood groups, blood typing and blood transfusions." Accessed September 2, 2011. http://www.nobelprize.org/educational/medicine/landsteiner/readmore.html
- Plucker, Jonathan. "Human intelligence: Hermann Ebbinghaus." Indiana University. July 25, 2007. http://www.indiana.edu/~intell/ebbinghaus.shtml
- Sample, Ian. "Who are the hardest, bravest men and women in the history of science?" The Guardian. November 12, 2010. http://www.guardian.co.uk/science/blog/2010/nov/11/hardest-bravest-science
- Stratton, George M. "Some preliminary experiments on vision without inversion of the retinal image." International Congress for Psychology. August 1896. http://www.cns.nyu.edu/~nava/courses/psych_and_brain/pdfs/Stratton_1896.pdfs
- Tweney, Dylan. "LSD inventor Albert Hofmann dead at age 102." Wired. April 29, 2008. http://www.wired.com/wiredscience/2008/04/lsd-inventor-al/
- Van Rensburg, Lee. "Radial nerve." Royal College of Surgeons of Edinburgh. August 19, 2004. http://www.rcsed.ac.uk/fellows/lvanrensburg/classification/nerves/radialnerve.htm
- Voytek, Bradley. "Sir Henry Head's self-experimentation." Oscillatory Thoughts. September 9, 2010. http://blog.ketyov.com/2010/09/self-experimentation-sir-henry-head-and.html
- Watt-Smith, Tiffany. "Henry Head and the Theatre of Reverie." Interdisciplinary Studies in the Long Nineteenth Century. 2011. http://www.19.bbk.ac.uk/index.php/19/article/view/595/719
- Smith, Molly M. "Energy expenditure at rest and physical activity; McArdle, Katch and Katch; Chapter 8." Weber State University. Accessed September 6, 2011. http://www.google.com/url?sa=t&source=web&cd=9&sqi=2&ved=0CFYQFjAI&url=http%3A%2F%2Ffaculty.weber.edu%2Fmmsmith1%2F3510pwrpt%2FEnergy8%2520Expenditure.ppt&rct=j&q=total%20daily%20energy%20expenditure%20average%20person&ei=vYVmTtuIJM3SgQfLqOCgCg&usg=AFQjCNEoU0VF0Kcw4geIoAZ8j-Jm24wxXg&cad=rja
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