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How long does it take for Zoloft to work?

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Author's Note: How long does it take for Zoloft to work?

Zoloft and other antidepressants take a few weeks to work. This is information I've heard before. What I'd never heard, however, was "why." The idea that Zoloft increases the levels of serotonin -- a mood-boosting chemical in the brain -- almost immediately after taking the first few doses was a new one to me. But what really astounded me was the idea that in response, the brain is physically changing. Growing new receptors. Absorbing serotonin in greater amounts. And, in turn, affecting mood and behavior. The human body is amazing.

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  • Medicine Net. "Antidepressants." May 31, 2013. (Sept. 15, 2013) http://www.medicinenet.com/antidepressants/page4.htm
  • National Alliance on Mental Illness. "Zoloft (Sertraline)." (Sept. 15, 2013) http://www.nami.org/Template.cfm?Section=About_Medications&template=/ContentManagement/ContentDisplay.cfm&ContentID=8197
  • National Center for Health Statistics. "Antidepressant Use in Persons Aged 12 and Over: United States, 2005-2008." October 2011. (Sept. 15, 2013) http://www.cdc.gov/nchs/data/databriefs/db76.pdf
  • National Institute of Mental Health. "Antidepressant Medications for Children and Adolescents: Information for Parents and Caregivers." (Sept. 15, 2013) http://www.nimh.nih.gov/health/topics/child-and-adolescent-mental-health/antidepressant-medications-for-children-and-adolescents-information-for-parents-and-caregivers.shtml
  • RX List. "Zoloft." (Sept. 15, 2013) http://www.rxlist.com/zoloft-drug.htm
  • U.S. Food and Drug Administration. "Antidepressant Use in Children, Adolescents and Adults." (Sept. 15, 2013) http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm096273.htm
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