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How DNA Works

By: Craig Freudenrich, Ph.D. & Jennifer Walker-Journey  | 

What DNA Does

DNA carries all the information for your physical characteristics, which are essentially determined by proteins. DNA contains the instructions for making a protein. In DNA, each protein is encoded by a gene (a specific sequence of DNA nucleotides that specify how a single protein is to be made). Specifically, the order of nucleotides within a gene specifies the order and types of amino acids that must be put together to make a protein.

A protein is made of a long chain of chemicals called amino acids. There are various types of proteins with different functions:

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  • Enzymes carry out chemical reactions (such as digestive enzymes).
  • Structural proteins are building materials (such as collagen and nail keratin).
  • Transport proteins that carry substances (such as oxygen-carrying hemoglobin in blood).
  • Contraction proteins (such as actin and myosin) cause muscles to compress.
  • Storage proteins that hold on to substances, such as albumin in egg whites and iron-storing ferritin in your spleen.
  • Hormones (including insulin, estrogen, testosterone and cortisol) send signals between the cells in the body.

The particular sequence of amino acids in the chain is what makes one protein different from another. This sequence is encoded in the DNA where one gene encodes for one protein.

How does DNA encode the information for a protein? There are only four DNA bases, but there are 20 amino acids that can be used for proteins. So, groups of three nucleotides form a codon that specifies which of the 20 amino acids goes into the protein. A 3-base codon yields 64 possible patterns (4*4*4), which is more than enough to specify 20 amino acids.

Because there are 64 possible codons and only 20 amino acids, there is some repetition in the genetic code. Also, the order of codons in the gene specifies the order of amino acids in the protein. It may require anywhere from 100 to 1,000 codons (300 to 2,000 nucleotides) to specify a given protein. Each gene also has codons to designate the beginning (start codon) and end (stop codon) of the gene.

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